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DoxyPEP
Explained

Everything you need to know about doxycycline post-exposure prophylaxis — and how to get it

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DoxyPEP 101

DoxyPEP reduces the risk of contracting syphilis, chlamydia and gonorrhea when taken after condomless sex.

Studies have proven DoxyPEP is effective in reducing STI risk among men who have sex with men, trans women and other gender-diverse people born with a penis.

DoxyPEP is taken ideally within 24 hours, but no later than 72 hours, after having condomless oral, anal or vaginal intercourse.

Freddie patients who are eligible to take DoxyPEP can get it prescribed alongside PrEP (which prevents HIV).

What is DoxyPEP?

DoxyPEP is short for doxycycline post-exposure prophylaxis. It’s a medication that reduces your risk of contracting syphilis, chlamydia or gonorrhea when taken after a potential exposure, such as having unprotected (condomless) anal, oral or vaginal intercourse.

Who is DoxyPEP for?

DoxyPEP is for men who have sex with men, trans women and other gender-diverse people who were born with a penis. Studies show that in people with this body type, DoxyPEP reduced the risk of chlamydia by 70-89%, syphilis by 73-87%, and gonorrhea by 51-57%.

Research suggests DoxyPEP is not as effective when taken by cis women, trans men, and other gender-diverse people born with vaginas, so it isn’t currently recommended for people with this body type. However, you can still speak with your clinician to determine what’s right for you.

DoxyPEP may also be right for you if you:

have had a bacterial STI in the past year and have had condomless anal or oral sexual contact with ≥ 1 cis male or trans female partner in the past year

have a history of syphilis infection 

have had multiple cis male or trans female sex partners in the prior year, even if you have not previously been diagnosed with an STI


DoxyPEP may NOT be right for you if you:

have a known allergy to doxycycline or tetracycline medication

have a known diagnosis of Myasthenia Gravis

use certain medications such as barbiturates, phenytoin, carbamazepine, isotretinoin, or others

are pregnant or able to get pregnant

are breast or chest feeding

DoxyPEP 101

DoxyPEP reduces the risk of contracting syphilis, chlamydia and gonorrhea when taken after condomless sex.

Studies have proven DoxyPEP is effective in reducing STI risk among men who have sex with men, trans women and other gender-diverse people born with a penis.

DoxyPEP is taken ideally within 24 hours, but no later than 72 hours, after having condomless oral, anal or vaginal intercourse.

Freddie patients who are eligible to take DoxyPEP can get it prescribed alongside PrEP.

How to take DoxyPEP

DoxyPEP is a pill taken orally as a single 200mg dose, typically consisting of two 100mg tablets.


Typical dose of 2x 100mg tablets

DoxyPEP must be taken within 72 hours after having condomless sex to be effective at preventing STIs.

Ideally, DoxyPEP should be taken within 24 hours after having condomless sex. DoxyPEP may be more effective the sooner you take it after an exposure.

For DoxyPEP to be the most effective, it needs to be taken every time you have condomless sex.

Avoid dairy or metal-containing supplements (calcium, magnesium, zinc, antacids), which can reduce DoxyPEP's efficacy, for two hours before and after your dose.

TAKE A FREE
ASSESSMENT
Find out if DoxyPEP and PrEP are right for you by completing Freddie's self-assessment.

It assesses your risk of contracting STIs and will let you know what your options are to protect yourself.

It's 100% confidential and free.
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Is DoxyPEP safe? YES!

Doxycycline (DoxyPEP) is a widely-used antibiotic with a low risk of side effects and drug interactions.

Doxycycline can make you more sensitive to sunlight, so it’s important to wear sunscreen for at least 24 hours after you’ve taken it.

Doxycycline can cause nausea, but taking it with food can help this. Don't lie down lie down for 30 minutes after taking it.

Why take both PrEP & DoxyPEP?

DoxyPEP can reduce the risk of syphilis, chlamydia and gonorrhea — but it doesn’t protect against other STIs, including HIV.

However, HIV can be prevented with PrEP (pre-exposure prophylaxis), a pill that can reduce your risk of HIV by up to 99%.

By taking both PrEP and DoxyPEP, you can greatly reduce your risk of contracting multiple STIs. And Freddie makes it easy to get PrEP & DoxyPEP together.

How to get PrEP & DoxyPEP

Get prescribed PrEP & DoxyPEP online and have it delivered to your door in just a few steps. (DoxyPEP is only available to patients who also get PrEP from Freddie.)

Short questionnaire and call

1

Answer a few questions and book your free appointment with an expert Freddie clinician.

Complete your lab work

2

Get some basic tests done so we can determine if PrEP and DoxyPEP is safe for you.

Get your prescription

3

Your results are reviewed by your Freddie clinician. If PrEP and DoxyPEP are safe for you, your prescription will be delivered discreetly to your door!

Get PrEP & DoxyPEP
Just want PrEP instead?
Just want PrEP instead?
If you decide you're more interested in solely taking PrEP to prevent HIV, and not in DoxyPEP, Freddie can still help!

Freddie is the #1 PrEP provider in Canada, and over 90% of Freddie patients pay $0 for PrEP.

Plus, PrEP is available 100% virtually — no calls required!
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