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DoxyPEP
Explained

Everything you need to know about doxycycline post-exposure prophylaxis — and how to get it

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DoxyPEP 101

DoxyPEP can help protect you against some bacterial STIs when taken after condomless sex.

DoxyPEP can reduce STI risk among men who have sex with men, trans women and other gender-diverse people born with a penis.

DoxyPEP is taken ideally within 24 hours, but no later than 72 hours, after having condomless oral, anal or vaginal intercourse.

Freddie patients who are eligible to take DoxyPEP can get it prescribed alongside PrEP (which can help prevent HIV).

What is DoxyPEP?

DoxyPEP is short for doxycycline post-exposure prophylaxis. It’s a medication that reduces your risk of contracting some STIs when taken after a potential exposure, such as having unprotected (condomless) anal, oral or vaginal intercourse.

Who is DoxyPEP for?

DoxyPEP can reduce STI risk among men who have sex with men, trans women and other gender-diverse people born with a penis.

Research suggests DoxyPEP is not as effective when taken by cis women, trans men, and other gender-diverse people born with vaginas, so it isn’t currently recommended for people with this body type. However, you can still speak with your clinician to determine what’s right for you.

DoxyPEP may also be right for you if you:

have had a bacterial STI in the past year and have had condomless anal or oral sexual contact with ≥ 1 cis male or trans female partner in the past year

have a history of syphilis infection 

have had multiple cis male or trans female sex partners in the prior year, even if you have not previously been diagnosed with an STI


DoxyPEP may NOT be right for you if you:

have a known allergy to doxycycline or tetracycline medication

have a known diagnosis of Myasthenia Gravis

use certain medications such as barbiturates, phenytoin, carbamazepine, isotretinoin, or others

are pregnant or able to get pregnant

are breast or chest feeding

DoxyPEP 101

DoxyPEP reduces the risk of contracting syphilis, chlamydia and gonorrhea when taken after condomless sex.

Studies have proven DoxyPEP is effective in reducing STI risk among men who have sex with men, trans women and other gender-diverse people born with a penis.

DoxyPEP is taken ideally within 24 hours, but no later than 72 hours, after having condomless oral, anal or vaginal intercourse.

Freddie patients who are eligible to take DoxyPEP can get it prescribed alongside PrEP.

How to take DoxyPEP

DoxyPEP is a pill taken orally as a single 200mg dose, typically consisting of two 100mg tablets.

DoxyPEP must be taken within 72 hours after having condomless sex to be effective at preventing STIs.

Ideally, DoxyPEP should be taken within 24 hours after having condomless sex. DoxyPEP may be more effective the sooner you take it after an exposure.

For DoxyPEP to be the most effective, it needs to be taken every time you have condomless sex.

Avoid dairy or metal-containing supplements (calcium, magnesium, zinc, antacids), which can reduce DoxyPEP's efficacy, for two hours before and after your dose.

Talk to a Clinician
Our team of expert clinicians are here to help you learn more about PrEP and DoxyPEP and find out if they're right for you.

Get started by taking a fast, free online assessment that determines your STI risk.
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Is DoxyPEP safe? YES!

Doxycycline (DoxyPEP) is a widely-used antibiotic with a low risk of side effects and drug interactions.

Doxycycline can make you more sensitive to sunlight, so it’s important to wear sunscreen for at least 24 hours after you’ve taken it.

Doxycycline can cause nausea, but taking it with food can help this. Don't lie down for 30 minutes after taking it.

Why take both PrEP & DoxyPEP?

PrEP

Get started with PrEP & DoxyPEP

Find out of PrEP and DoxyPEP are right for you by talking to an expert Freddie clinician.

DoxyPEP is only available to patients who also get PrEP from Freddie.

Short questionnaire and call

1

Answer a few questions and book your free appointment with an expert Freddie clinician.

Complete your lab work

2

Get some basic tests done so we can determine if PrEP and DoxyPEP are safe for you.

Receive your prescription

3

Your results are reviewed by your Freddie clinician. If PrEP and DoxyPEP are safe for you, your prescription will be delivered discreetly to your door!

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Just want PrEP instead?
Just want PrEP instead?
If you decide you're more interested in solely taking PrEP to prevent HIV, and not in DoxyPEP, Freddie can still help!

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